Introduction of histidine units using benzotriazolide activation
Kiran Bajaj, Siva S. Panda, Mohamed A. Ibrahim, Said A. El-Feky, Alan R. Katritzky, J. Pept. Sci., 2013, 19, 110–117.
DOI: 10.1002/psc.2483
Nα-Boc-Nim-(4-toluenesulfonyl-l-histidylbenzotriazole) enables convenient acylation of N-, O-, S-, and C-nucleophiles with no detectable racemization. We report efficient syntheses of novel histidine-containing di-, tri-, and tetra-peptides and models for the preparation of potentially biologically active histidine N-, O-, S-, and C-conjugates. Copyright © 2013 European Peptide Society and John Wiley & Sons, Ltd.
Keyword: Research Peptides